What is 5-HTP?

5-hydroxytryptophan (5-HTP) is a supplement that the body makes from the amino acid tryptophan. It is used to help increase levels of serotonin, a chemical in the brain that affects mood, sleep, and behavior 

What is it used for? 

• Studied for depression, OCD (as add-on), and mood symptoms in Parkinson’s disease. 

• Not established for routine use; more high-quality studies are needed to confirm effectiveness. 

How does it work? 

• 5-HTP is converted to serotonin, a neurotransmitter regulating mood, sleep, and behavior. 

How should it be taken? 

• Dose varies; follow product instructions. 

• Avoid combining with serotonergic drugs unless supervised. 

Possible side effects 

Common: Nausea, vomiting, stomach pain, restlessness, or agitation. Rare: Serotonin syndrome or allergic reactions. 

Special considerations 

• Quality of supplements varies, risk of impurities and contamination. 

• Use with caution if on antidepressants or other serotonin-boosting drugs. 

• Not enough safety data for pregnancy/breastfeeding. 

• Seek urgent care if symptoms of serotonin syndrome occur (confusion, fever, muscle stiffness). 

• Only use under medical supervision for mental health purposes.